Biocompatible PEDOT:Nafion composite electrode coatings for selective detection of neurotransmitters in vivo

Vreeland, et al.

2021 - present

2016 - 2020

Bartlett MJ, Mabrouk OS, Szabò L, Flores AJ, Parent KL, Bidlack JM, Heien ML, Kennedy RT, Polt R, Sherman SJ, Falk T.
The Delta-Specific Opioid Glycopeptide BBI-11008: CNS Penetration and Behavioral Analysis in a Preclinical Model of Levodopa-Induced Dyskinesia.
Int J Mol Sci. 2020 Dec 22;22(1):20. doi: 10.3390/ijms22010020.
PMID: 33374986 Free PMC article.

66. Gage SL, Kramer CL, Calle S, Carroll M, Heien ML, DeGrandi-Hoffman G. Nosema ceranae parasitism impacts olfactory learning and memory and neurochemistry in honey bees (Apis mellifera). Journal of Experimental Biology. 2018 221(Pt 4). doi: 10.1242/jeb.161489, PMID: 29361577

65. Hill DF, Parent KL, Atcherley CW, Cowen SL, Heien ML. Differential release of dopamine in the nucleus accumbens evoked by low-versus high-frequency medial prefrontal cortex stimulation. Brain Stimulation. 2018 11(2), 426 - 434: doi: 10.1016/j.brs.2017.11.010, PMID: 29239776

64. Abdalla A, Atcherley CW, Pathirathna P, Samaranayake S, Qiang B, Peña E, Morgan SL, Heien ML, Hashemi P. In Vivo Ambient Serotonin Measurements at Carbon-Fiber Microelectrodes. Analytical Chemistry. 2017 89(18), 9703 - 9711. doi: 10.1021/acs.analchem.7b01257, PMID: 28795565

63. Parent KL, Hill DF, Crown LM, Wiegand JP, Gies KF, Miller MA, Atcherley CW, Heien ML, Cowen SL. Platform to Enable Combined Measurement of Dopamine and Neural Activity. Analytical Chemistry. 2017 89 (5), 2790 – 2799. doi: 10.1021/acs.analchem.6b03642, PMID: 28211999

62. Meier AR, Bahureksa WA, Heien ML. Elucidating the Structure-Function Relationship of Poly(3,4-theylenedioxythiophene) Films to Advance Electrochemical Measurements. Journal of Physical Chemistry C. 2016 120(37), 21114 - 21122. doi: 10.1021/acs.jpcc.6b04622

61. Meier AR, Matteucci M, Vreeland RF, Taboryski R, Heien ML. Rapid Voltammetric Measurements at Conducting Polymer Microelectrodes Using Ultralow-Capacitance Poly(3,4-ethylenedioxythiophene):Tosylate. Langmuir. 2016 32(32), 8009 - 18. doi: 10.1021/acs.langmuir.6b01423, PMID: 27483032

60. Bartlett MJ, Joseph RM, LePoidevin LM, Parent KL, Laude ND, Lazarus LB, Heien ML, Estevez M, Sherman SJ, Falk T. Long-term effect of sub-anesthetic ketamine in reducing L-DOPA-induced dyskinesias in a preclinical model. Neuroscience Letters. 2016 612, 121 - 5. doi: 10.1016/j.neulet.2015.11.047, PMID: 26644333

2011 - 2015

59. Burrell MH, Atcherley CW, Heien ML, Lipski J. A novel electrochemical approach for prolonged measurement of absolute levels of extracellular dopamine in brain slices. ACS Chemical Neuroscience. 2015 6(11), 1802 - 12. doi: 10.1021/acschemneuro.5b00120, PMID: 26322962

58. Heien ML. Response to Comment on "Improved Calibration of Voltammetric Sensors for Studying Pharmacological Effects on Dopamine Transporter Kinetics in Vivo". ACS Chemical Neuroscience. 2015 6(9), 1652 - 6. doi: 10.1021/acschemneuro.5b00131, PMID: 26241706

57. Vreeland RF, Atcherley CW, Russell WS, Xie JY, Lu D, Laude ND, Porreca F, Heien ML. Biocompatible PEDOT:Nafion composite electrode coatings for selective detection of neurotransmitters in vivo. Analytical Chemistry. 2015 87(5), 2600 - 7. doi: 10.1021/ac502165f, PMID: 25692657

56. Atcherley CW, Wood KM, Parent KL, Hashemi P, Heien ML. The coaction of tonic and phasic dopamine dynamics. Chemical Communications. 2015 51(12), 2235 - 8. doi: 10.1039/c4cc06165a, PMID: 25249291

55. Atcherley CW, Laude ND, Monroe EB, Wood KM, Hashemi P, Heien ML. Improved Calibration of Voltammetric Sensors for Studying Pharmacological Effects on Dopamine Transporter Kinetics in Vivo. ACS Chemical Neuroscience. 2015 6(9), 1509 - 16. doi: 10.1021/cn500020s, PMID: 25062330

54. Pathirathna P, Samaranayake S, Atcherley CW, Parent KL, Heien ML, McElmurry SP, Hashemi P. Fast Voltammetry of Metals at Carbon-Fiber Microelectrodes: Copper Adsorption onto Activated Carbon aids Rapid Electrochemical Analysis. Analyst. 2014 139(18), 4673 - 80. doi: 10.1039/c4an00937a, PMID: 25051455

53. Dong Y, Ning G, Ewing AG, Heien ML. Pituitary adenylate cyclase activating polypeptide modulates catecholamine storage and exocytosis in PC12 cells. PLoS One. 2014, 9(3): e91132. doi: 10.1371/journal.pone.0091132, PMID: 24603879

52. Flores AJ, Bartlett MJ, So LY, Laude ND, Parent KL, Heien ML, Sherman SJ, Falk T. Differential effects of the NMDA receptor antagonist MK-801 on dopamine receptor D1- and D2-induced abnormal involuntary movements in a preclinical model. Neuroscience Letters. 2014, 564, 48-52. doi: 10.1016/j.neulet.2014.02.004, PMID: 24525249

51. Vreeland RF, Laude ND, Lambert SM, Heien ML. Microwave-Plasma Dry-Etch for Fabrication of Conducting Polymer Microelectrodes. Analytical Chemistry. 2014, 86(3), 1385−1390. doi: 10.1021/ac403363a, PMID: 24417474

50. Atcherley CW, Laude ND, Parent KL, Heien ML. Fast-Scan Controlled-Adsorption Voltammetry for the Quantification of Absolute Concentrations and Adsorption Dynamics. Langmuir. 2013 29(48), 14885 – 14892. doi: 10.1021/la402686s, PMID: 24245864

49. Atcherley CW, Vreeland RF, Monroe EB, Sanchez-Gomez E, Heien ML. Rethinking data collection and signal processing. 2. Preserving the temporal fidelity of electrochemical measurements. Analytical Chemistry. 2013 85(16), 7654 - 7658. doi: 10.1021/ac402037k, PMID: 23919317

48. Monroe EB, Heien ML. Electrochemical generation of hydroxyl radicals for examining protein structure. Analytical Chemistry. 2013 85(13), 6185 - 6189. doi: 10.1021/ac400107c, PMID: 23777226

47. Berglund EC, Makos MA, Keighron JD, Phan N, Heien ML, Ewing AG. Oral administration of methylphenidate blocks the effect of cocaine on uptake at the Drosophila dopamine transporter. ACS Chemical Neuroscience. 2013 4(4), 566 - 574. doi: 10.1021/cn3002009, PMID: 23402315

46. Omiatek DM, Bressler AJ, Cans AS, Andrews AM, Heien ML, Ewing AG. The real catecholamine content of secretory vesicles in the CNS revealed by electrochemical cytometry. Scientific Reports. 2013 3(1447). doi: 10.1038/srep01447, PMID: 23486177

45. Laude ND, Atcherley CW, Heien ML. Rethinking data collection and signal processing. 1. Real-time oversampling filter for chemical measurements. Analytical Chemistry. 2012 84(19), 8422 - 8426. doi: 10.1021/ac302169y, PMID: 22978644

44. Larsen ST, Heien ML, Taboryski R. Amperometric noise at thin film band electrodes. Analytical Chemistry. 2012 84(18), 7744 - 7749. doi: 10.1021/ac301136x, PMID: 22928986

43. Larsen ST, Vreeland RF, Heien ML, Taboryski R. Characterization of poly(3,4-ethylenedioxythiophene):tosylate conductive polymer microelectrodes for transmitter detection. Analyst. 2012 137(8), 1831 - 1836. doi: 10.1039/c2an16288a, PMID: 22383043

42. Ariansen JL, Heien ML, Hermans A, Phillips PE, Hernadi I, Bermudez MA, Schultz W, Wightman RM. Monitoring extracellular pH, oxygen, and dopamine during reward delivery in the striatum of primates. Frontiers in Behavioral Neuroscience. 2012 6(36). doi: 10.3389/fnbeh.2012.00036, PMID: 22783176

41. Zhang B, Heien ML, Santillo MF, Mellander L, Ewing AG. Temporal resolution in electrochemical imaging on single PC12 cells using amperometry and voltammetry at microelectrode arrays. Analytical Chemistry. 2011 83(2), 571 - 577. doi: 10.1021/ac102502g, PMID: 21190375

40. Santillo MF, Ewing AG, Heien ML. Trends in computational simulations of electrochemical processes under hydrodynamic flow in microchannels. Analytical and Bioanalytical Chemistry. 2011 399(1), 183 - 190. doi: 10.1007/s00216-010-4070-4, PMID: 20734034

2006 - 2010

39. Dong Y, Heien ML, Kurczy ML, Ewing AG. Probing Exocytosis at single cells using electrochemistry. In Chemical Cytometry: Ultrasensitive analysis of single cells, Lu C, Ed. Wiley-VCH. 2010, 159-174.

38. Dominak LM, Omiatek DM, Gundermann EL, Heien ML, Keating CD. Polymeric crowding agents improve passive biomacromolecule encapsulation in lipid vesicles. Langmuir. 2010 26(16), 13195 - 13200. doi: 10.1021/la101903r, PMID: 20695558

37. Omiatek DM, Cans AS, Heien ML, Ewing AG. Analytical approaches to investigate transmitter content and release from single secretory vesicles. Analytical and Bioanalytical Chemistry. 2010 397(8), 3269 - 3279. doi: 10.1007/s00216-010-3698-4, PMID: 20480152

36. Makos MA, Omiatek DM, Ewing AG, Heien ML. Development and characterization of a voltammetric carbon-fiber microelectrode pH sensor. Langmuir. 2010 26(12), 10386 - 10391. doi: 10.1021/la100134r, PMID: 20380393

35. Kurczy ME, Piehowsky PD, Willingham D, Molyneaux KA, Heien ML, Winograd N, Ewing AG. Nanotome cluster bombardment to recover spatial chemistry after preparation of biological samples for SIMS imaging. Journal of the American Society for Mass Spectrometry. 2010 21(5), 833 - 836. doi: 10.1016/j.jasms.2010.01.014, PMID: 20219392

34. Omiatek DM, Dong Y, Heien ML, Ewing AG. Only a Fraction of Quantal Content is Released During Exocytosis as Revealed by Electrochemical Cytometry of Secretory Vesicles. ACS Chemical Neuroscience. 2010 1(3), 234 - 245. doi: 10.1021/cn900040e, PMID: 20368748

33. Kurczy ME, Piehowski PD, Van Bell CT, Heien ML, Winograd N, Ewing AG. Mass spectrometry imaging of mating Tetrahymena show that changes in cell morphology regulate lipid domain formation. Proceedings of the National Academy of Sciences USA. . 2010 107(7), 2751 - 2756. doi: 10.1073/pnas.0908101107, PMID: 20133641

32. Adams KL, Engelbrektsson J, Voinova M, Zhang B, Eves DJ, Karlsson R, Heien ML, Cans AS, Ewing AG. Steady-state electrochemical determination of lipidic nanotube diameter utilizing an artificial cell model. Analytical Chemistry. 2010 82(3). 1020 - 1026. doi: 10.1021/ac902282d, PMID: 20039639

31. Makos MA, Han KA, Heien ML, Ewing AG. Using In Vivo Electrochemistry to Study the Physiological Effects of Cocaine and Other Stimulants on the Drosophila melanogaster Dopamine Transporter. ACS Chemical Neuroscience. 2010 1(1), 74 - 83. doi: 10.1021/cn900017w, PMID: 20352129

30. Heien ML, Piehowski PD, Winograd N, Ewing AG. Lipid detection, identification, and imaging single cells with SIMS. Methods in Molecular Biology. 2010 656, 85 - 97. doi: 10.1007/978-1-60761-746-4_4, PMID: 20680585

29. Makos MA, Kuklinski NJ, Berglund EC, Heien ML, Ewing AG. Chemical Measurements in Drosophila. Trends in Analytical Chemistry. 2009 28(11), 1223-1234. doi: 10.1016/j.trac.2009.08.005, PMID: 20161412

28. Santillo MF, Heien ML, Ewing AG. Temporal analysis of protozoan lysis in a microfluidic device. Lab on a Chip. 2009 9(19), 2796 - 2802. doi: 10.1039/b907942d, PMID: 19967116

27. Keithley RM, Heien ML, Wightman RM. Multivariate concentration determination using principal component regression with residual analysis. Trends in Analytical Chemistry. 2009, 28(9), 1127 - 1136. doi:10.1016/j.trac.2009.07.002, PMID: 20160977

26. Piehowski PD, Davey AM, Kurczy ME, Sheets ED, Winograd N, Ewing AG, Heien ML. ToF-SIMS imaging of sub-cellular lipid heterogeneity: Poisson counting and spatial resolution. Analytical Chemistry. 2009 81(14), 5593-5602. doi: 10.1021/ac901065s, PMID: 19530687

25. Omiatek DM, Santillo MF, Heien ML, Ewing AG. Hybrid capillary-microfluidic device for the separation, lysis, and electrochemical detection of vesicles. Analytical Chemistry. 2009 81(6), 2294 - 2302. doi: 10.1021/ac802466g, PMID: 19228035

24. Makos MA, Kim YC, Han KA, Heien ML, Ewing AG. In Vivo Electrochemical measurements of exogenously applied dopamine in Drosophila melanogaster. Analytical Chemistry. 2009 81(5), 1848 – 1854. doi: 10.1021/ac802297b, PMID: 19192966

23. Hanson JN, Motala MJ, Heien ML, Gillette M, Sweedler J, Nuzzo RG. Textural guidance cues for controlling process outgrowth of mammalian neurons. Lab on a Chip. 2009 9(1), 122 - 131. doi: 10.1039/b803595d, PMID: 19209344

22. Heien ML, Ewing AG. Quantitative chemical analysis of single cells. Microfluidics and Nanotechnology, Humana Press Methods in Molecular Biology series. 2009 544, 153 - 162. doi: 10.1007/978-1-59745-483-4_11, PMID: 19488699

21. Dong Y, Heien ML, Maxon MM, Ewing AG. Amperometric measurements of catecholamine release from single vesicles in MN9D cells. Journal of Neurochemistry. 2008 107(6), 1589 - 1595. doi: 10.1111/j.1471-4159.2008.05721.x, PMID: 19094057

20. Piehowski PD, Carado A, Kurczy ME, Ostrowski S, Heien ML, Winograd N, Ewing AG. MS/MS methodology to improve sub-cellular mapping of cholesterol using ToF-SIMS. Analytical Chemistry. 2008 80(22), 8662 - 8667. doi: 10.1021/ac801591r, PMID: 18925746

19. Piehowski PD, Kurczy ME, Willingham D, Parry S, Heien ML, Winograd N, Ewing AG. Freeze-etching and vapor matrix deposition for ToF-SIMS imaging of single cells. Langmuir. 2008 24(15), 7906 - 7911. doi: 10.1021/la800292e, PMID: 18570446

18. Zhang B, Adams KL, Luber SJ, Eves DJ, Heien ML, Ewing AG. Spatially and temporally resolved single-cell exocytosis utilizing individually addressable carbon microelectrode arrays. Analytical Chemistry. 2008 80(5), 1394 - 1400. doi: 10.1021/ac702409s, PMID: 18232712

17. Jo K, Heien ML, Thompson LB, Zhong M, Nuzzo RG, Sweedler JV. Mass spectrometric imaging of peptide release from neuronal cells within microfluidic devices. Lab on a Chip. 2007 7(11), 1454 - 1460. doi: 10.1039/b706940e, PMID: 17960271

16. Wightman RM, Heien ML, Wassum KM, Sombers LA, Aragona BJ, Khan AS, Ariansen JL, Cheer JF, Phillips PE, Carelli RM. Dopamine release is heterogeneous within microenvironments of the rat nucleus accumbens. European Journal of Neuroscience. 2007 26(7), 2046 - 2054. doi: 10.1111/j.1460-9568.2007.05772.x, PMID: 17868375

15. Cheer JF, Aragona BJ, Heien ML, Seipel AT, Carelli RM, Wightman RM. Coordinated accumbal dopamine release and neural activity drive goal-directed behavior. Neuron. 2007 54(2), 237 - 244. doi: 10.1016/j.neuron.2007.03.021, PMID: 17442245

14. Cheer JF, Wassum KM, Sombers LA, Heien ML, Ariansen JL, Aragona BJ, Phillips PE, Wightman RM. Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation. Journal of Neuroscience. 2007 27(4), 791 - 795. doi: 10.1523/JNEUROSCI.4152-06.2007, PMID: 17251418

13. Rubakhin SS, Hatcher NG, Monroe EB, Heien ML, Sweedler JV. Mass spectrometric imaging of the nervous system. Current Pharmaceutical Design. 2007 13(32), 3325 - 3334. PMID: 18045186

12. Heien ML, Wightman RM. Phasic dopamine signaling during behavior, reward, and disease states. CNS Neurological Disorders - Current Drug Targets. 2006 5(1), 99 - 108. PMID: 16613556

2002 - 2005

11. Cheer JF, Heien ML, Garris PA, Carelli RM, Wightman RM.
Simultaneous dopamine and single-unit recordings reveal accumbens GABAergic responses: implications for intracranial self-stimulation.
Proceedings of the National Academy of Sciences USA. 2005 102(52) 19150 - 19155.
doi: 10.1073/pnas.0509607102, PMID: 16380429

10. Heien ML, Khan AS, Ariansen JL, Cheer JF, Phillips PEM, Wassum KM, Wightman RM.
Real-time measurement of dopamine fluctuations after cocaine in the brain of behaving rats.
Proceedings of the National Academy of Sciences USA. 2005 102(29), 10023 - 10028.
doi: 10.1073/pnas.0504657102, PMID: 16006505

9. Heien ML, Johnson MA, Wightman RM.
Resolving neurotransmitters detected by fast-scan cyclic voltammetry.
Analytical Chemistry. 2004 76(19), 5697 - 5704.
doi: 10.1021/ac0491509, PMID: 15456288

8. Forry SP, Murray JR, Heien ML, Locascio LE, Wightman RM.
Probing electric fields inside microfluidic channels during electroosmotic flow with fast-scan cyclic voltammetry.
Analytical Chemistry. 2004 76(17), 4945 - 4950.
doi: 10.1021/ac049591s, PMID: 15373427

7. Song Y, Heien ML, Jimenez V, Wightman RM, Murray RW.
Voltammetric detection of metal nanoparticles separated by liquid chromatography.
Analytical Chemistry. 2004 76(17), 4911 - 4919.
doi: 10.1021/ac049223o, PMID: 15373423

6. Cheer JF, Wassum KM, Heien ML, Phillips PEM, Wightman RM.
Cannabinoids enhance subsecond dopamine release in the nucleus accumbens of awake rats.
Journal of Neuroscience. 2004 24(18), 4393 - 4400.
doi: 10.1523/jneurosci.0529-04.2004, PMID: 15128853

5. Heien ML, Phillips PEMP, Stuber GD, Seipel AT, Wightman RM.
Overoxidation of carbon-fiber microelectrodes enhances dopamine adsorption and increases sensitivity.
Analyst. 2003 128(12), 1413 - 1419.
doi: 10.1039/b307024g, PMID: 14737224

4. Robinson DL, Venton BJ, Heien ML, Wightman RM.
Detecting subsecond dopamine release with fast-scan cyclic voltammetry in vivo.
Clinical Chemistry. 2003 49(10), 1763 - 1773.
doi: 10.1373/49.10.1763, PMID: 14500617

3. Phillips PEMP, Stuber GD, Heien ML, Wightman RM, Carelli RM.
Subsecond dopamine release promotes cocaine seeking.
Nature. 2003 422(6932), 614 - 618.
doi: 10.1038/nature01476, PMID: 12687000

2. Robinson DL, Heien ML, Wightman RM.
Frequency of dopamine concentration transients increases in dorsal and ventral striatum of male rats during introduction of conspecifics.
Journal of Neuroscience. 2002 22(23), 10477 – 10486.
PMID: 12451147

1. Troyer KP, Heien ML, Venton BJ, Wightman RM.
Neurochemistry and electroanalytical probes.
Current Opinions in Chemical Biology. 2002 6(5), 696 - 703.
doi: 10.1016/s1367-5931(02)00374-5, PMID: 12413556

Non-reviewed publications

Heien ML, Sweedler JV. Solution to the neurochemical challenge. Analytical and Bioanalytical Chemistry. 2007 388(1), 3. doi: 10.1007/s00216-007-1200-8

Heien ML, Sweedler JV. Neurochemical challenge. Analytical and Bioanalytical Chemistry. 2007 387(1), 3-4. doi: 10.1007/s00216-006-0932-1

Heien ML, Wightman RM. Carbon-Fiber Microelectrodes: Fabrication and Treatments. Axobits. 2004 41, 5-6.